氫分子醫學的新啟示：一些臨床藥物的奇怪作用

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這個觀點實際上與我去年的文章是類似的，我們去年提出的觀點是內源性氫是一種抗氧化物質，這個文章的觀點是有些糖尿病藥物，可抑制能量物質吸收，有一個明顯的副作用是大腸內產生氣體，這類藥物往往具有器官保護作用。過去一直不明白為什麼這樣。日本學者提出的這個觀點，我是非常同意。過去1年我們課題組多次討論到這個話題。可惜我們沒有把這個觀點形成文章。真的十分可惜。

Hypothesis

Are the effects of α-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?

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Yoshihiko Suzuki^a, Motoaki Sano^{c, ,} , Kentaro Hayashida^c, Ikuroh Ohsawa^{a, b}, Shigeo Ohta^a and Keiichi Fukuda^c

^aDepartment of Biochemistry and Cell Biology, Institute of Development and Aging Science, Graduate School of Medicine, Nippon Medical School, Kawasaki City 211-8533, Japan
^bThe Center of Molecular Hydrogen Medicine, Institute of Development and Aging Science, Graduate School of Medicine, Nippon Medical School, Kawasaki City 211-8533, Japan
^cDepartment of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo 160-8582, Japan

Received 20 April 2009;

revised 28 May 2009;

accepted 31 May 2009.

Available online 8 June 2009.

Abstract

The major side-effect of treatment with α-glucosidase inhibitors, flatulence, occurs when undigested carbohydrates are fermented by colonic bacteria, resulting in gas formation. We propose that the cardiovascular benefits of α-glucosidase inhibitors are partly attributable to their ability to neutralise oxidative stress via increased production of H₂ in the gastrointestinal tract. Acarbose, which is an α-glucosidase inhibitor, markedly increased H₂ production, with a weaker effect on methane production. Our hypothesis is based on our recent discovery that H₂ acts as a unique antioxidant, and that when inhaled or taken orally as H₂-dissolved water it ameliorates ischaemia–reperfusion injury and atherosclerosis development.

Keywords: α-Glucosidase inhibitors; Type 2 diabetes; Hydrogen gas; Antioxidant

Article Outline

1. Introduction

2. Molecular hydrogen (H₂) acts as a novel antioxidant

3. Unexpected benefit of flatulence caused by α-glucosidase inhibitors

4. Conclusion

Conflict of interest statement

Acknowledgements

References

Fig. 1. Effects of acarbose on the levels of exhaled H₂ and CH₄. The values shown in the bar graphs are means ± S.D.

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Table 1.
Eleven healthy volunteers (10 males and 1 female) were administered acarbose at a dosage of 300 mg/day (100 mg three times a day) for 4 days under free-feeding conditions. Exhaled gas was collected in an aluminium bag at the point of mid-expiration at the indicated time-points (i.e., morning, before lunch, 2 h after lunch, before retiring), both before and after acarbose treatment. The exhaled gas samples were injected into the Breath Gas Analyzer to measure the H₂ and CH₄ concentrations.

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Corresponding author. Address: Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo 160-8582, Japan. Fax: +81 3 5363 3875.
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